منابع مشابه
Glycosaminoglycan Chains and Axon Regeneration
Specific sensory input to neocortex arrives in layer 4, whereas nonspecific input, such as information about salience or novelty, is thought to arrive in layer 1. This scheme might imply a slower arrival of inputs to layer 1. In this issue, Zhu and Zhu examine this question using paired whole-cell recording in vivo from layer 1 nonpyramidal cells and the dendrites of the output pyramidal neuron...
متن کاملInhibition of Axonal Regeneration*
Because axonal damage and loss are frequent phenomena of multiple sclerosis and other types of neurodegenerative diseases, and because the effects can be devastating clinically, attention has been focused on repair to axons. However, axon regeneration appears to be inhibited via a variety of possible cellular pathways and molecules. In the following article, several of these pathways are examin...
متن کاملProtein deacetylases and axonal regeneration
A neuron with injured or severed axon responds with attempts at axonal regrowth. In this regard, axonal regeneration of peripheral nerves occurs far more efficiently compared to central nervous system (CNS) neurons. The latter typically could not form a proper growth cone, and any axonal regeneration in vivo is very limited. The adult CNS environment is not conducive for axonal regrowth. An ext...
متن کاملIntegrins promote axonal regeneration after injury of the nervous system: Integrins and axonal regeneration
Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in...
متن کاملRetinoic acid signaling in axonal regeneration
Following an acute central nervous system (CNS) injury, axonal regeneration and functional recovery are extremely limited. This is due to an extrinsic inhibitory growth environment and the lack of intrinsic growth competence. Retinoic acid (RA) signaling, essential in developmental dorsoventral patterning and specification of spinal motor neurons, has been shown through its receptor, the transc...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2021
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.702179